Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 4/20 | 0.34 |
| ▸ | DRD1 | P21728 | 4/20 | 0.34 |
| ▸ | DRD4 | P21917 | 4/20 | 0.34 |
| ▸ | DRD5 | P21918 | 4/20 | 0.34 |
| ▸ | DRD3 | P35462 | 4/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4700323 | 0.84 | OPRM1 (0.60) | OPRM1OPRD1OPRK1KCNH2ACHE | |
| Citric Acid SCHEMBL4755344 | 0.75 | OPRM1 (0.59) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4699399 | 0.74 | OPRM1 (0.56) | OPRM1OPRD1OPRK1KCNH2ACHE | |
| Citric Acid SCHEMBL4755341 | 0.74 | OPRM1 (0.57) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4755342 | 0.72 | OPRM1 (0.65) | OPRM1OPRD1OPRK1KCNH2 | |
| Citric Acid SCHEMBL4699202 | 0.72 | OPRM1 (0.81) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4697637 | 0.71 | OPRM1 (0.71) | OPRM1OPRD1OPRK1KCNH2ACHE | |
| SCHEMBL6484166 | 0.70 | OPRM1 (0.47) | OPRM1OPRD1OPRK1KCNH2DRD3 | |
| Citric Acid SCHEMBL5458523 | 0.69 | OPRM1 (0.75) | OPRM1OPRD1OPRK1KCNH2 | |
| SCHEMBL4700315 | 0.68 | OPRM1 (0.54) | OPRM1OPRD1OPRK1KCNH2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1440059-B1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES AS OPIOID RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2008-04-16 | — | — | EP | disclosed |