Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PTGES | O14684 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703839 | 0.86 | SMN1; SMN2 (0.47) | KMT2ASMN1; SMN2HPGDF2MAPT | |
| SCHEMBL4706287 | 0.83 | BDKRB1 (0.47) | KMT2ASMN1; SMN2HPGDF2MAPT | |
| SCHEMBL4789522 | 0.80 | BDKRB1 (0.54) | KMT2ASMN1; SMN2HPGDF2MAPT | |
| SCHEMBL4704250 | 0.79 | ITGB1 (0.49) | KMT2ASMN1; SMN2HPGDF2MAPT | |
| SCHEMBL4704255 | 0.78 | BDKRB1 (0.48) | KMT2ABDKRB1RAB9ANPC1ALDH1A1 | |
| SCHEMBL4788480 | 0.76 | BDKRB1 (0.43) | KMT2ASMN1; SMN2HPGDF2MAPT | |
| SCHEMBL4703909 | 0.75 | BDKRB1 (0.68) | BDKRB1 | |
| SCHEMBL4706728 | 0.75 | POLB (0.51) | KMT2ASMN1; SMN2CYP1A2CYP2C9 | |
| SCHEMBL4704544 | 0.75 | BDKRB1 (0.44) | KMT2ASMN1; SMN2HPGDF2MAPT | |
| SCHEMBL4035233 | 0.75 | BDKRB1 (0.55) | KMT2ASMN1; SMN2HPGDF2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |