Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 13/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705143 | 0.92 | BDKRB1 (0.49) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL6045946 | 0.90 | BDKRB1 (0.49) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL4706254 | 0.88 | BDKRB1 (0.46) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL4704915 | 0.84 | BDKRB1 (0.47) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL4789049 | 0.84 | BDKRB1 (0.47) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL6046042 | 0.84 | BDKRB1 (0.52) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL4702394 | 0.82 | BDKRB1 (0.44) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL6045883 | 0.79 | BDKRB1 (0.50) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL6045941 | 0.78 | BDKRB1 (0.49) | BDKRB1POLBKMT2AKDM4ETDP1 | |
| SCHEMBL4702157 | 0.78 | KMT2A (0.45) | BDKRB1KMT2ATDP1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |