Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.78 |
| ▸ | OXTR | P30559 | 6/20 | 0.48 |
| ▸ | CCKBR | P32239 | 5/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 5/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 5/20 | 0.46 |
| ▸ | CCKAR | P32238 | 1/20 | 0.45 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4697415 | 0.99 | KCNH2 (0.77) | KCNH2OXTRCCKBRHDAC3HDAC4 | |
| SCHEMBL4698132 | 0.91 | KCNH2 (0.68) | KCNH2OXTRCCKBRHDAC3HDAC4 | |
| SCHEMBL7091166 | 0.88 | KCNH2 (1.00) | KCNH2OXTRCCKBRHDAC3HDAC4 | |
| SCHEMBL4702249 | 0.88 | KCNH2 (0.64) | KCNH2OXTRCCKBRCCKARPSEN1 | |
| Hydrochloric Acid SCHEMBL4755895 | 0.87 | KCNH2 (0.63) | KCNH2OXTRCCKBRCCKARPSEN1 | |
| SCHEMBL4697333 | 0.87 | KCNH2 (0.66) | KCNH2CCKBRHDAC3HDAC4HDAC1 | |
| SCHEMBL4699817 | 0.86 | KCNH2 (0.62) | KCNH2OXTRCCKBRCCKARPSEN1 | |
| Hydrochloric Acid SCHEMBL6003884 | 0.86 | KCNH2 (0.60) | KCNH2OXTRCCKBRCCKARPSEN1 | |
| SCHEMBL4697879 | 0.84 | KCNH2 (0.62) | KCNH2OXTRCCKBRCCKARPSEN1 | |
| SCHEMBL4699922 | 0.82 | KCNH2 (0.59) | KCNH2CCKBRHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326849-B1 | BENZODIAZEPINE DERIVATIVES AS INHIBITORS OF GAMMA SECRETASE | MERCK SHARP & DOHME (GB) | 2008-07-16 | — | — | EP | claimed |