Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.68 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL462962 | 0.92 | CYP3A4 (0.59) | CYP3A4NR1I2KDM4EALDH1A1LMNA | |
| SCHEMBL459591 | 0.92 | CYP3A4 (0.59) | CYP3A4NR1I2KDM4EALDH1A1LMNA | |
| SCHEMBL15254001 | 0.85 | CYP3A4 (0.75) | CYP3A4NR1I2PSIP1 | |
| SCHEMBL470388 | 0.85 | NR1I2 (0.63) | CYP3A4NR1I2KDM4EALDH1A1LMNA | |
| SCHEMBL10175637 | 0.85 | CYP3A4 (0.51) | CYP3A4NR1I2KDM4EALDH1A1LMNA | |
| SCHEMBL12091027 | 0.81 | NR1I2 (0.63) | CYP3A4NR1I2KDM4EALDH1A1LMNA | |
| Bi-224436 SCHEMBL29450566 | 0.81 | CYP3A4 (1.00) | CYP3A4NR1I2KDM4EALDH1A1MAPT | |
| SCHEMBL12091046 | 0.81 | NR1I2 (0.68) | CYP3A4NR1I2KDM4EALDH1A1LMNA | |
| Bi-224436 SCHEMBL12987894 | 0.81 | CYP3A4 (1.00) | CYP3A4NR1I2KDM4EALDH1A1MAPT | |
| SCHEMBL470345 | 0.81 | NR1I2 (0.58) | CYP3A4NR1I2KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8633200-B2 | Inhibitors of human immunodeficiency virus replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-01-21 | — | — | US | disclosed |
| US-8633200-B2 | Inhibitors of human immunodeficiency virus replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-01-21 | — | — | US | disclosed |
| US-20120225888-A1 | Inhibitors of Human Immunodeficiency Virus Replication | BRISTOL-MYERS SQUIBB COMPANY | 2012-09-06 | — | — | US | disclosed |
| US-20120225888-A1 | Inhibitors of Human Immunodeficiency Virus Replication | BRISTOL-MYERS SQUIBB COMPANY | 2012-09-06 | — | — | US | disclosed |
| WO-2012033735-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225888-A1 | Inhibitors of Human Immunodeficiency Virus Replication | EIF2AK2, RTF2, MAVS | CYP3A4 1719/4885NR1I2 3085/4885KDM4E 2143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.