Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 6/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.42 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459270 | 0.83 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL470211 | 0.81 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL13190186 | 0.80 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL457173 | 0.79 | PIK3CA (0.45) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL13190540 | 0.77 | PIK3CA (0.42) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL10280417 | 0.75 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL10187722 | 0.73 | PIK3CG (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL470092 | 0.73 | PIK3CA (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL458644 | 0.72 | PIK3CD (0.68) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 | |
| SCHEMBL470096 | 0.71 | PIK3CD (0.61) | PIK3CDPIK3CAPIK3CGPIK3CBPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012032065-A1 | INDAZOLE DERIVATIVES FOR USE IN THE TREATMENT OF INFLUENZA VIRUS INFECTION | GLAXO GROUP LIMITED (GB) | 2012-03-15 | — | — | WO | disclosed |
| WO-2010102958-A1 | 4-OXADIAZOL-2 -YL- INDAZOLES AS INHIBITORS OF P13 KINASES | GLAXO GROUP LIMITED (GB) | 2010-09-16 | — | — | WO | disclosed |