Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703374 | 1.00 | HPGD (0.40) | HPGDSMN1; SMN2NR1H4P2RX7TSHR | |
| SCHEMBL3089762 | 0.90 | HPGD (0.47) | HPGDSMN1; SMN2P2RX7TSHRCRHR1 | |
| SCHEMBL3089759 | 0.90 | HPGD (0.47) | HPGDSMN1; SMN2P2RX7TSHRCRHR1 | |
| SCHEMBL3079706 | 0.88 | HPGD (0.49) | HPGDSMN1; SMN2P2RX7TSHRCRHR1 | |
| SCHEMBL13538061 | 0.81 | HPGD (0.51) | HPGDSMN1; SMN2P2RX7TSHRCRHR1 | |
| SCHEMBL1518397 | 0.71 | KMT2A (0.40) | MCHR1 | |
| SCHEMBL1518400 | 0.71 | KMT2A (0.40) | MCHR1 | |
| SCHEMBL1072117 | 0.71 | P2RX7 (0.43) | HPGDSMN1; SMN2P2RX7CRHR2 | |
| SCHEMBL15809160 | 0.70 | MRGPRX4 (0.48) | HPGDPTGES | |
| SCHEMBL1518229 | 0.69 | MCHR1 (0.47) | SMYD3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893578-A2 | NOVEL PIPERIDINE CARBOXYLIC ACID AMIDE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006129237-A2 | NOVEL PIPERIDINE CARBOXYLIC ACID AMIDE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2006-12-07 | — | — | WO | disclosed |