Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 9/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.35 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703245 | 0.90 | BDKRB1 (0.54) | BDKRB1SMN1; SMN2GPR139KMT2AHPGD | |
| SCHEMBL4789160 | 0.90 | BDKRB1 (0.61) | BDKRB1SMN1; SMN2GPR139KMT2AHPGD | |
| SCHEMBL4790151 | 0.90 | BDKRB1 (0.61) | BDKRB1SMN1; SMN2GPR139KMT2AHPGD | |
| SCHEMBL4705721 | 0.89 | BDKRB1 (0.53) | BDKRB1SMN1; SMN2GPR139KMT2AHPGD | |
| SCHEMBL4706286 | 0.89 | BDKRB1 (0.53) | BDKRB1SMN1; SMN2GPR139KMT2AHPGD | |
| SCHEMBL4701982 | 0.89 | BDKRB1 (0.52) | BDKRB1SMN1; SMN2GPR139KMT2AHPGD | |
| SCHEMBL4705076 | 0.88 | BDKRB1 (0.52) | BDKRB1SMN1; SMN2GPR139KMT2AHPGD | |
| SCHEMBL6046075 | 0.88 | BDKRB1 (0.55) | BDKRB1SMN1; SMN2GPR139PHGDHKMT2A | |
| SCHEMBL4705421 | 0.81 | BDKRB1 (0.46) | BDKRB1SMN1; SMN2GPR139KMT2AHPGD | |
| SCHEMBL4704918 | 0.81 | BDKRB1 (0.46) | BDKRB1SMN1; SMN2KMT2AHPGDF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |