Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 8/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703245 | 0.92 | BDKRB1 (0.54) | BDKRB1SMN1; SMN2MAPK1KMT2AF2 | |
| SCHEMBL4789160 | 0.92 | BDKRB1 (0.61) | BDKRB1SMN1; SMN2MAPK1RAB9AKMT2A | |
| SCHEMBL4790151 | 0.92 | BDKRB1 (0.61) | BDKRB1SMN1; SMN2MAPK1RAB9AKMT2A | |
| SCHEMBL4706286 | 0.91 | BDKRB1 (0.53) | BDKRB1SMN1; SMN2ALDH1A1RAB9AKMT2A | |
| SCHEMBL4705721 | 0.91 | BDKRB1 (0.53) | BDKRB1SMN1; SMN2RAB9AKMT2ATAS1R3 | |
| SCHEMBL4701982 | 0.90 | BDKRB1 (0.52) | BDKRB1SMN1; SMN2MAPK1KMT2AF2 | |
| SCHEMBL6045959 | 0.88 | BDKRB1 (0.56) | BDKRB1SMN1; SMN2HSP90AA1HSP90AB1ALDH1A1 | |
| SCHEMBL4703765 | 0.88 | BDKRB1 (0.50) | BDKRB1SMN1; SMN2MAPK1ALDH1A1KMT2A | |
| SCHEMBL4705421 | 0.83 | BDKRB1 (0.46) | BDKRB1SMN1; SMN2KMT2AF2MAPT | |
| SCHEMBL4704918 | 0.82 | BDKRB1 (0.46) | BDKRB1SMN1; SMN2ALDH1A1KMT2AF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |