Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.37 |
| ▸ | ALKBH3 | Q96Q83 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470412 | 0.86 | MAPT (0.40) | MAPTPOLBKDM4EGAAKDM5B | |
| SCHEMBL470433 | 0.86 | KDM4E (0.41) | MAPTPOLBKDM4EGAAKDM5B | |
| SCHEMBL2054043 | 0.82 | AURKA (0.47) | MAPTPOLBKDM4EGAAKDM5B | |
| SCHEMBL2042831 | 0.81 | MAPT (0.39) | MAPTPOLBKDM4EGAAKDM5B | |
| SCHEMBL470323 | 0.81 | MAPT (0.52) | MAPTPOLBKDM4EGAAALDH1A1 | |
| SCHEMBL2043538 | 0.79 | KDM4E (0.42) | MAPTPOLBKDM4EGAAKDM5B | |
| SCHEMBL2042378 | 0.76 | ALDH1A1 (0.52) | MAPTPOLBKDM4EGAAALDH1A1 | |
| SCHEMBL15475992 | 0.76 | NPC1 (0.53) | MAPTPOLBKDM4EGAAALDH1A1 | |
| SCHEMBL457202 | 0.76 | DPP4 (0.52) | MAPTPOLBKDM4EALDH1A1TP53 | |
| SCHEMBL459528 | 0.74 | MAPT (0.46) | MAPTPOLBKDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012033735-A1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |