Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704256 | 1.00 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| SCHEMBL9828860 | 0.94 | SMN1; SMN2 (0.53) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| Water SCHEMBL27944924 | 0.92 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| SCHEMBL17939720 | 0.92 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| SCHEMBL11796686 | 0.92 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| SCHEMBL26122722 | 0.92 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| SCHEMBL11800511 | 0.92 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| SCHEMBL27905915 | 0.92 | SMN1; SMN2 (0.51) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| SCHEMBL28031785 | 0.91 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A | |
| SCHEMBL28032316 | 0.91 | SMN1; SMN2 (0.50) | ALDH1A1SMN1; SMN2MAPK1L3MBTL1PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599471-B1 | HYDROXYMETHYL SUBSTITUTED DIHYDROISOXAZOLE DERIVATIVES USEFUL AS ANTIBIOTIC AGENTS | ASTRAZENECA AB (SE) | 2008-05-28 | — | — | EP | disclosed |
| EP-0157963-B1 | 6H-DIBENZ (B,E)(1,4)OXATHIEPIN COMPOUNDS | MERCK & CO. INC. (US) | 1989-06-21 | — | — | EP | disclosed |
| US-4778897-A | 6H-dibenz[b,e][1,4]oxathiepin compounds | MERCK & CO., INC. (US) | 1988-10-18 | — | — | US | disclosed |
| US-4699917-A | Anti-asthmatic tetrazolyl 6H-dibenz-[B,E]-[1,4]-oxathiepin derivatives, compositions, and method of use therefor | MERCK & CO., INC. (US) | 1987-10-13 | — | — | US | disclosed |
| EP-0069810-B1 | NOVEL DIBENZOXEPINS, THEIR PREPARATION, COMPOSITIONS CONTAINING THEM AND THE USE OF DIBENZOXEPINS IN THE TREATMENT OF ALLERGIC CONDITIONS | MERCK & CO. INC. (US) | 1986-12-03 | — | — | EP | disclosed |
| US-4582842-A | Anti-asthmatic 6H-dibenz-[b,e] [1,4]oxathiepin derivatives, compositions, and method of use therefor | MERCK & CO., INC. (US) | 1986-04-15 | — | — | US | disclosed |
| EP-0157963-A1 | 6H-dibenz (b,e)(1,4)oxathiepin compounds | MERCK & CO. INC. (US) | 1985-10-16 | — | — | EP | disclosed |
| US-4536507-A | ANTIASTHMA AGENTS | MERCK & CO., INC. (US) | 1985-08-20 | — | — | US | disclosed |
| US-4394515-A | 10,11-Dihydro-11-oxodibenzo[b,f]thiepin compounds | MERCK & CO., INC. (US) | 1983-07-19 | — | — | US | disclosed |
| EP-0069810-A1 | Novel dibenzoxepins, their preparation, compositions containing them and the use of dibenzoxepins in the treatment of allergic conditions | MERCK & CO. INC. (US) | 1983-01-19 | — | — | EP | disclosed |
| EP-0000978-B1 | 7-AND 8-SUBSTITUTED -10,11-DIHYDRO-11-OXODIBENZO (B,F) THIEPIN DERIVATIVES, THEIR PRODUCTION AND THEIR PARMACEUTICAL COMPOSITIONS | MERCK & CO. INC. (US) | 1982-09-15 | — | — | EP | disclosed |
| US-4282365-A | Dibenz[b,e]oxepin compounds | MERCK & CO., INC. (US) | 1981-08-04 | — | — | US | disclosed |
| US-4263207-A | ANTIALLERGENS | MERCK & CO., INC. (US) | 1981-04-21 | — | — | US | disclosed |
| EP-0011067-A1 | Prostaglandin antagonists, their production and their pharmaceutical compositions | MERCK & CO. INC. (US) | 1980-05-28 | — | — | EP | disclosed |
| EP-0000978-A1 | 7-and 8-substituted -10,11-dihydro-11-oxodibenzo (b,f) thiepin derivatives, their production and their parmaceutical compositions | MERCK & CO. INC. (US) | 1979-03-07 | — | — | EP | disclosed |