Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706296 | 0.91 | CHEK1 (0.49) | CHEK1IKBKBALDH1A1 | |
| SCHEMBL4217714 | 0.85 | CHEK1 (0.65) | CHEK1POLBACHEIKBKB | |
| SCHEMBL4702522 | 0.80 | CHEK1 (0.61) | CHEK1 | |
| SCHEMBL4705870 | 0.79 | CHEK1 (0.46) | CHEK1IKBKB | |
| SCHEMBL4703834 | 0.78 | CHEK1 (0.47) | CHEK1IKBKB | |
| SCHEMBL4704847 | 0.78 | CHEK1 (0.56) | CHEK1IKBKB | |
| SCHEMBL4704773 | 0.78 | CHEK1 (0.53) | CHEK1IKBKBMAPT | |
| SCHEMBL4704552 | 0.77 | CHEK1 (0.60) | CHEK1IKBKB | |
| SCHEMBL4706388 | 0.77 | CHEK1 (0.49) | CHEK1IKBKB | |
| SCHEMBL4216101 | 0.76 | CHEK1 (0.59) | CHEK1IKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |