Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 4/20 | 0.41 |
| ▸ | DRD3 | P35462 | 4/20 | 0.41 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP12 | P39900 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4704577 | 0.91 | CHEK1 (0.55) | CHEK1IKBKBALDH1A1 | |
| SCHEMBL4216101 | 0.86 | CHEK1 (0.59) | CHEK1HTR4IKBKB | |
| SCHEMBL4702677 | 0.79 | CHEK1 (0.55) | CHEK1IKBKB | |
| SCHEMBL4704839 | 0.79 | CHEK1 (0.55) | CHEK1IKBKB | |
| SCHEMBL4706749 | 0.78 | CHEK1 (0.59) | CHEK1 | |
| SCHEMBL4706388 | 0.77 | CHEK1 (0.49) | CHEK1IKBKB | |
| SCHEMBL4704773 | 0.76 | CHEK1 (0.53) | CHEK1IKBKBFAAH | |
| SCHEMBL4217714 | 0.76 | CHEK1 (0.65) | CHEK1HTR4IKBKB | |
| SCHEMBL4703022 | 0.76 | CHEK1 (0.55) | CHEK1 | |
| SCHEMBL4705785 | 0.76 | CHEK1 (0.55) | CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |