Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL470395 | 0.89 | TSHR (0.52) | TSHRMAPK1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL470304 | 0.89 | TSHR (0.51) | TSHRMAPK1KDM4EMAPTLMNA | |
| SCHEMBL10087686 | 0.87 | TSHR (0.56) | TSHRMAPK1KDM4EMAPTLMNA | |
| SCHEMBL12523352 | 0.85 | TSHR (0.54) | TSHRMAPK1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL12457267 | 0.82 | TSHR (0.51) | TSHRMAPK1KDM4EMAPTLMNA | |
| SCHEMBL457357 | 0.81 | TSHR (0.53) | TSHRMAPK1KDM4EMAPTLMNA | |
| SCHEMBL10087685 | 0.80 | TSHR (0.55) | TSHRMAPK1KDM4EMAPTLMNA | |
| SCHEMBL457864 | 0.80 | TSHR (0.55) | TSHRMAPK1KDM4EMAPTLMNA | |
| SCHEMBL470242 | 0.79 | TSHR (0.49) | TSHRMAPK1KDM4EMAPTLMNA | |
| SCHEMBL16374973 | 0.79 | TSHR (0.51) | TSHRMAPK1KDM4EMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012033736-A1 | NOVEL PIPERAZINE ANALOGS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-15 | — | — | WO | disclosed |