Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 10/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.37 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.37 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706682 | 0.94 | CYP1A2 (0.43) | SIGMAR1BDKRB1HPGDF2MAPT | |
| SCHEMBL4704544 | 0.88 | BDKRB1 (0.44) | BDKRB1HPGDF2MAPTKMT2A | |
| SCHEMBL4703958 | 0.87 | BDKRB1 (0.41) | SIGMAR1BDKRB1HPGDF2MAPT | |
| SCHEMBL14084810 | 0.87 | SIGMAR1 (0.48) | SIGMAR1BDKRB1ABL1SRCHPGD | |
| SCHEMBL4788480 | 0.87 | BDKRB1 (0.43) | BDKRB1HPGDF2MAPTKMT2A | |
| SCHEMBL4703831 | 0.86 | HDAC3 (0.42) | BDKRB1HPGDPOLBF2MAPT | |
| SCHEMBL4704165 | 0.84 | BDKRB1 (0.40) | BDKRB1HPGDPOLBF2MAPT | |
| SCHEMBL4789400 | 0.84 | BDKRB1 (0.43) | BDKRB1HPGDF2MAPTKMT2A | |
| SCHEMBL4702475 | 0.84 | BDKRB1 (0.42) | BDKRB1HPGDF2MAPTKMT2A | |
| SCHEMBL4702172 | 0.82 | BDKRB1 (0.47) | BDKRB1HPGDF2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633348-B1 | 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B sb 1 /sb RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES | ELAN PHARM INC (US) | 2008-10-08 | — | — | EP | claimed |