Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.37 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22699195 | 0.75 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL22699269 | 0.74 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL22699224 | 0.74 | KDM4E (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL22699230 | 0.71 | NPC1 (0.47) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL22699218 | 0.70 | MAPT (0.39) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL4705999 | 0.69 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL14954867 | 0.69 | MAPT (0.64) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL22699072 | 0.68 | NPC1 (0.44) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL4705357 | 0.65 | NPC1 (0.50) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT | |
| SCHEMBL4703593 | 0.61 | NPC1 (0.51) | ALDH1A1SMN1; SMN2KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871776-A2 | FUSED THIENO[2,3-B]PYRIDINE AND THIAZOLO[5,4-B]PYRIDINE COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | SCHERING CORPORATION (US) | 2008-01-02 | — | — | EP | disclosed |
| WO-2006098961-A2 | FUSED THIENO [2, 3-B] PYRIDINE AND THIAZOLO [5, 4-B] PYRIDINE COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY | SCHERING CORPORATION (US) | 2006-09-21 | — | — | WO | disclosed |