Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.53 |
| ▸ | RAF1 | P04049 | 9/20 | 0.53 |
| ▸ | BRAF | P15056 | 9/20 | 0.53 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703449 | 0.81 | MAPK14 (0.67) | MAPK14HSPB1LCK | |
| SCHEMBL12459071 | 0.76 | NPC1 (0.74) | MAPK14RAF1BRAFHSPB1 | |
| SCHEMBL2345369 | 0.76 | RARB (0.66) | MAPK14RAF1BRAFHSPB1 | |
| SCHEMBL5641957 | 0.75 | MAPK14 (0.66) | MAPK14HSPB1 | |
| SCHEMBL2346857 | 0.75 | MAPT (0.64) | MAPK14RAF1BRAFHSPB1 | |
| SCHEMBL2352480 | 0.74 | PKM (0.70) | MAPK14RAF1BRAF | |
| SCHEMBL4703314 | 0.74 | MAPK14 (0.64) | MAPK14HSPB1LCKCSF1R | |
| SCHEMBL4703306 | 0.74 | MAPK14 (0.64) | MAPK14HSPB1 | |
| SCHEMBL2347292 | 0.74 | RAF1 (0.66) | MAPK14RAF1BRAF | |
| SCHEMBL2345177 | 0.74 | MAPK14 (0.62) | MAPK14RAF1BRAFHSPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436272-B1 | BIPHENYLCARBOXYLIC AMIDE DERIVATIVES AS P38 KINASE INHIBITORS | GLAXO GROUP LTD (GB) | 2008-05-07 | — | — | EP | claimed |