Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.55 |
| ▸ | CDK2AP1 | O14519 | 7/20 | 0.55 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
| ▸ | KIFC1 | Q9BW19 | 2/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706739 | 0.96 | CHEK1 (0.61) | CHEK1CDK2AP1DGAT2 | |
| SCHEMBL4704094 | 0.96 | CHEK1 (0.51) | CHEK1CDK2AP1DGAT2FAAHROCK1 | |
| SCHEMBL4705874 | 0.94 | CHEK1 (0.59) | CHEK1CDK2AP1DGAT2KDM4ESMN1; SMN2 | |
| SCHEMBL4704507 | 0.90 | CHEK1 (0.60) | CHEK1CDK2AP1 | |
| SCHEMBL4218387 | 0.90 | CHEK1 (0.69) | CHEK1CDK2AP1 | |
| SCHEMBL4702659 | 0.90 | CHEK1 (0.58) | CHEK1CDK2AP1KDM4EMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL4219793 | 0.90 | CHEK1 (0.68) | CHEK1CDK2AP1 | |
| SCHEMBL4703075 | 0.86 | CHEK1 (0.73) | CHEK1CDK2AP1 | |
| SCHEMBL4220643 | 0.86 | CHEK1 (0.75) | CHEK1CDK2AP1 | |
| SCHEMBL4224436 | 0.86 | CHEK1 (0.64) | CHEK1CDK2AP1FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |