Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.58 |
| ▸ | CDK2AP1 | O14519 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4705874 | 0.96 | CHEK1 (0.59) | CHEK1CDK2AP1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL4704094 | 0.94 | CHEK1 (0.51) | CHEK1CDK2AP1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL4704507 | 0.92 | CHEK1 (0.60) | CHEK1CDK2AP1 | |
| SCHEMBL4705911 | 0.90 | CHEK1 (0.55) | CHEK1CDK2AP1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL4218235 | 0.89 | CHEK1 (0.73) | CHEK1CDK2AP1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL4706363 | 0.88 | KDM4E (0.46) | CHEK1KDM4ESMN1; SMN2RAB9APOLB | |
| SCHEMBL4706739 | 0.86 | CHEK1 (0.61) | CHEK1CDK2AP1 | |
| SCHEMBL4215015 | 0.85 | CHEK1 (0.74) | CHEK1CDK2AP1 | |
| SCHEMBL4702912 | 0.85 | CHEK1 (0.78) | CHEK1CDK2AP1 | |
| SCHEMBL4224436 | 0.83 | CHEK1 (0.64) | CHEK1CDK2AP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |