Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.49 |
| ▸ | GPR183 | P32249 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12064798 | 0.89 | GPR119 (0.40) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL470613 | 0.88 | GPR119 (0.49) | GPR119GPR183KCNH2DPP4 | |
| SCHEMBL12064614 | 0.87 | GPR119 (0.49) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12064792 | 0.87 | GPR119 (0.45) | GPR119GPR183KCNH2 | |
| SCHEMBL12064555 | 0.83 | GPR119 (0.35) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL470544 | 0.82 | GPR119 (0.50) | GPR119GPR183KCNH2 | |
| SCHEMBL470648 | 0.81 | GPR119 (0.49) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12064786 | 0.81 | GPR119 (0.40) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL470604 | 0.80 | GPR119 (0.49) | GPR119GPR183KCNH2DPP4 | |
| SCHEMBL121162 | 0.80 | GPR119 (0.42) | GPR119GPR183KCNH2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011147951-A1 | CYCLOAMINO DERIVATIVES AS GPR119 ANTAGONISTS | PROSIDION LIMITED (GB) | 2011-12-01 | — | — | WO | disclosed |