Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 3/20 | 0.39 |
| ▸ | BCR | P11274 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4790380 | 0.91 | INSR (0.49) | EGFRERBB2SLC2A1INSRABL1 | |
| SCHEMBL4703580 | 0.91 | SLC2A1 (0.43) | EGFRERBB2SLC2A1INSRABL1 | |
| SCHEMBL3537500 | 0.84 | EGFR (0.46) | EGFRERBB2SLC2A1INSRABL1 | |
| SCHEMBL3544183 | 0.81 | EGFR (0.49) | EGFRERBB2SLC2A1INSRABL1 | |
| SCHEMBL4705773 | 0.80 | SLC2A1 (0.35) | EGFRSLC2A1MAPK8MAPK9MAPK10 | |
| SCHEMBL3536948 | 0.79 | EGFR (0.51) | EGFRERBB2SLC2A1INSRMAPK8 | |
| SCHEMBL3537903 | 0.76 | INSR (0.51) | EGFRERBB2SLC2A1INSRABL1 | |
| SCHEMBL3540212 | 0.76 | SLC2A1 (0.46) | EGFRERBB2SLC2A1INSRMAPK8 | |
| SCHEMBL3536782 | 0.76 | SLC2A1 (0.45) | EGFRSLC2A1INSRABL1BCR | |
| SCHEMBL14875113 | 0.72 | MAPK8 (0.47) | EGFRERBB2SLC2A1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1971606-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-09-24 | — | — | EP | claimed |
| WO-2007067506-A2 | 2-PYRIMIDINYL PYRAZOLOPYRIDINE ERBB KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-06-14 | — | — | WO | claimed |