SCHEMBL4706331

SCHEMBL4706331

CN(C)c1nc(N)nc2cc(-c3ccccc3C(F)(F)F)c3c(ccn3CCO)c12

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 4/20 0.39
CYP2D6 P10635 3/20 0.39
CLK4 Q9HAZ1 3/20 0.39
CYP2C9 P11712 1/20 0.39
CYP3A4 P08684 3/20 0.36
TSHR P16473 3/20 0.36
USP2 O75604 2/20 0.36
CYP2C19 P33261 2/20 0.36
MAPK1 P28482 2/20 0.36
ALDH1A1 P00352 1/20 0.36
ACP1 P24666 1/20 0.36
GRIN2B Q13224 2/20 0.35
GRIN1 Q05586 1/20 0.35
PTPN1 P18031 7/20 0.35
SCN5A Q14524 1/20 0.35
SCN9A Q15858 1/20 0.35
TLR8 Q9NR97 1/20 0.33
HSD11B1 P28845 1/20 0.33
ALOX15 P16050 2/20 0.33
HSD17B10 Q99714 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL4710084 0.95 GRIN2B (0.38) CYP1A2CYP2D6CLK4CYP2C9CYP3A4
SCHEMBL4710085 0.88 GRIN2B (0.38) CYP1A2CYP2D6CLK4CYP2C9CYP3A4
SCHEMBL4688933 0.88 SLC2A1 (0.40) PTPN1SCN5ASCN9A
SCHEMBL4705957 0.87 CYP1A2 (0.42) CYP1A2CYP2D6CLK4CYP2C9CYP3A4
SCHEMBL4705995 0.83 PTPN1 (0.51) CYP1A2CYP2D6CLK4CYP3A4TSHR
Trifluoroacetic Acid SCHEMBL4707954 0.83 CYP1A2 (0.40) CYP1A2CYP2D6CLK4CYP2C9CYP3A4
Trifluoroacetic Acid SCHEMBL4691388 0.83 SCN5A (0.38) GRIN2BGRIN1PTPN1SCN5ASCN9A
SCHEMBL4707985 0.82 HSD11B1 (0.37) CYP1A2CYP2D6CLK4CYP2C9CYP3A4
SCHEMBL4705667 0.82 PTPN1 (0.38) CYP1A2CYP2D6CLK4CYP2C9GRIN2B
Trifluoroacetic Acid SCHEMBL4706828 0.79 PTPN1 (0.47) CYP1A2CYP2D6CLK4CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1633754-B1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS HOFFMANN LA ROCHE (CH) 2008-06-11 EP claimed
CN-100334088-C Diaminopyrroloquinazoline compounds as protein tyrosine phosphatase inhibitors HOFFMANN LA ROCHE CO LTD (CH) 2007-08-29 CN claimed
CN-1791604-A Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors HOFFMANN LA ROCHE (CH) 2006-06-21 CN claimed
EP-1633754-B1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS HOFFMANN LA ROCHE (CH) 2008-06-11 EP disclosed
CN-100334088-C Diaminopyrroloquinazoline compounds as protein tyrosine phosphatase inhibitors HOFFMANN LA ROCHE CO LTD (CH) 2007-08-29 CN disclosed
US-7226915-B2 Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors HOFFMANN-LA ROCHE INC. (US) 2007-06-05 US disclosed
US-7226915-B2 Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors HOFFMANN-LA ROCHE INC. (US) 2007-06-05 US disclosed
CN-1791604-A Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors HOFFMANN LA ROCHE (CH) 2006-06-21 CN disclosed
EP-1633754-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2006-03-15 EP disclosed
WO-2004101569-A1 DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS F. HOFFMANN-LA ROCHE AG (CH) 2004-11-25 WO disclosed