Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | IDH2 | P48735 | 3/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4706006 | 0.96 | PTPN1 (0.38) | PTPN1TLR7SYKAPPUSP1 | |
| SCHEMBL4705440 | 0.88 | PTPN1 (0.52) | PTPN1TLR7APPHSD11B1TLR8 | |
| SCHEMBL4707409 | 0.87 | PTPN1 (0.51) | PTPN1TLR7APPHSD11B1USP1 | |
| SCHEMBL4706007 | 0.86 | PTPN1 (0.36) | PTPN1TLR7APPHSD11B1DRD2 | |
| SCHEMBL4705744 | 0.86 | PTPN1 (0.46) | PTPN1TLR7APPTLR8 | |
| Trifluoroacetic Acid SCHEMBL5619985 | 0.85 | PTPN1 (0.47) | PTPN1TLR7APPTLR8 | |
| Trifluoroacetic Acid SCHEMBL4705990 | 0.85 | PTPN1 (0.46) | PTPN1TLR7APPUSP1WDR48 | |
| SCHEMBL4707590 | 0.84 | PTPN1 (0.48) | PTPN1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL4707248 | 0.84 | PTPN1 (0.42) | PTPN1TLR7TLR8 | |
| Trifluoroacetic Acid SCHEMBL4708662 | 0.82 | PTPN1 (0.49) | PTPN1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633754-B1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | claimed |
| EP-1633754-B1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| US-7226915-B2 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-7226915-B2 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-06-05 | — | — | US | disclosed |