Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 3/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | USP1 | O94782 | 2/20 | 0.36 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL4705990 | 0.94 | PTPN1 (0.46) | PTPN1NLRP3APPTLR8TLR7 | |
| SCHEMBL4705440 | 0.90 | PTPN1 (0.52) | PTPN1APPTLR8TLR7HSD11B1 | |
| SCHEMBL4707590 | 0.89 | PTPN1 (0.48) | PTPN1HSD11B1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL4705744 | 0.88 | PTPN1 (0.46) | PTPN1APPTLR8TLR7ACP1 | |
| SCHEMBL4706565 | 0.87 | PTPN1 (0.39) | PTPN1APPTLR8TLR7HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL5619985 | 0.85 | PTPN1 (0.47) | PTPN1APPTLR8TLR7CYP1A2 | |
| SCHEMBL4687979 | 0.85 | DHFR (0.46) | PTPN1HSD11B1 | |
| Trifluoroacetic Acid SCHEMBL4707248 | 0.84 | PTPN1 (0.42) | PTPN1TLR8TLR7ACP1CYP1A2 | |
| SCHEMBL5619987 | 0.84 | PTPN1 (0.39) | PTPN1TLR8TLR7CYP1A2CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4708662 | 0.83 | PTPN1 (0.49) | PTPN1HSD11B1CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633754-B1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | claimed |
| EP-1633754-B1 | DIAMINOPYRROLOQUINAZOLINES COMPOUNDS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2008-06-11 | — | — | EP | disclosed |
| CN-100334088-C | Diaminopyrroloquinazoline compounds as protein tyrosine phosphatase inhibitors | HOFFMANN LA ROCHE CO LTD (CH) | 2007-08-29 | — | — | CN | disclosed |
| US-7226915-B2 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-06-05 | — | — | US | disclosed |
| US-7226915-B2 | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2007-06-05 | — | — | US | disclosed |
| CN-1791604-A | Diaminopyrroloquinazolines compounds as protein tyrosine phosphatase inhibitors | HOFFMANN LA ROCHE (CH) | 2006-06-21 | — | — | CN | disclosed |