Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CTSS | P25774 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30898810 | 0.89 | MEN1 (0.60) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL3565164 | 0.89 | MEN1 (0.60) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL8384431 | 0.87 | MEN1 (0.51) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL6214741 | 0.86 | KMT2A (0.51) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL567435 | 0.85 | MEN1 (0.55) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL10885861 | 0.84 | MEN1 (0.53) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL503402 | 0.81 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL6380611 | 0.81 | MEN1 (0.57) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL16847676 | 0.81 | CTSK (0.52) | MEN1KMT2ASMN1; SMN2CA12CA1 | |
| SCHEMBL4442846 | 0.81 | KMT2A (0.60) | MEN1KMT2ASMN1; SMN2CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1597259-B1 | NITROGEN-SUBSTITUTED HEXAHYDROPYRAZINO 1,2-A PYRIMIDINE-4,7-DIONE DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | SANOFI AVENTIS DEUTSCHLAND (DE) | 2008-04-30 | — | — | EP | disclosed |