Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 9/20 | 0.46 |
| ▸ | TLR9 | Q9NR96 | 9/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 9/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.36 |
| ▸ | FEN1 | P39748 | 3/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | HCK | P08631 | 2/20 | 0.35 |
| ▸ | SRC | P12931 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.35 |
| ▸ | PRKDC | P78527 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262106 | 0.89 | TLR7 (0.45) | TLR7TLR9TLR8ALOX5APFEN1 | |
| SCHEMBL4047659 | 0.81 | TLR7 (0.60) | TLR7TLR9TLR8KDM5BKIT | |
| SCHEMBL4228716 | 0.74 | TLR7 (0.48) | TLR7TLR9TLR8MAPK1 | |
| SCHEMBL4262479 | 0.73 | TLR7 (0.61) | TLR7TLR9TLR8PIK3CDABL1 | |
| SCHEMBL4263914 | 0.72 | MERTK (0.38) | TLR7TLR9TLR8PIK3CDABL1 | |
| SCHEMBL4048637 | 0.72 | TLR7 (0.52) | TLR7TLR9TLR8ALOX5APFEN1 | |
| SCHEMBL4228277 | 0.71 | TLR7 (0.70) | TLR7TLR9TLR8PIK3CDABL1 | |
| SCHEMBL4216196 | 0.70 | TLR7 (0.59) | TLR7TLR9TLR8PIK3CDABL1 | |
| SCHEMBL4261490 | 0.70 | MERTK (0.52) | TLR7TLR9TLR8 | |
| SCHEMBL4215022 | 0.70 | TLR7 (0.74) | TLR7TLR9TLR8PIK3CDABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432714-B1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2008-08-06 | — | — | EP | disclosed |