Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4118504 | 0.94 | PI4KB (0.39) | MAPTPOLBALDH1A1PI4KBTSHR | |
| SCHEMBL4107810 | 0.92 | POLB (0.39) | MAPTPOLBALDH1A1PI4KBMKNK2 | |
| SCHEMBL4108347 | 0.92 | MKNK1 (0.38) | MAPTPOLBALDH1A1PI4KBMKNK2 | |
| SCHEMBL4116800 | 0.91 | PI4KB (0.40) | MAPTPOLBALDH1A1PI4KBTSHR | |
| SCHEMBL4102550 | 0.91 | POLB (0.38) | MAPTPOLBALDH1A1PI4KBTSHR | |
| SCHEMBL4101466 | 0.91 | MKNK2 (0.39) | MAPTPOLBALDH1A1PI4KBMKNK2 | |
| SCHEMBL4108372 | 0.89 | ALDH1A1 (0.39) | MAPTPOLBALDH1A1PI4KBTSHR | |
| SCHEMBL4121021 | 0.89 | ALDH1A1 (0.38) | MAPTPOLBALDH1A1PI4KBTSHR | |
| SCHEMBL4521469 | 0.89 | PDE4A (0.51) | MAPTPOLBALDH1A1PI4KBUSP2 | |
| SCHEMBL3922088 | 0.88 | ALDH1A1 (0.40) | MAPTPOLBALDH1A1PI4KBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899332-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C. | GILEAD SCIENCES, INC. (US) | 2008-03-19 | — | — | EP | disclosed |
| WO-2006135993-A1 | PYRIDO(3,2-D)PYRIMIDINES AND PHARMACEUTICAL COMPOSITIONS USEFUL FOR TREATING HEPATITIS C. | GILEAD SCIENCES, INC. (US) | 2006-12-28 | — | — | WO | disclosed |