Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 1/20 | 0.51 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RPA1 | P27694 | 7/20 | 0.41 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 2/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3811575 | 0.84 | MYC (0.57) | MYCNR4A1SMN1; SMN2TSHRCASP1 | |
| SCHEMBL31587364 | 0.84 | KMT2A (0.46) | SMN1; SMN2ABL1RPA1ALDH1A1POLB | |
| SCHEMBL14130008 | 0.83 | MYC (0.48) | MYCNR4A1AVPR2ALDH1A1NOTUM | |
| SCHEMBL15754746 | 0.81 | KMO (0.45) | SMN1; SMN2ABL1RPA1 | |
| SCHEMBL29229666 | 0.80 | AR (0.53) | ABL1RPA1 | |
| SCHEMBL30506384 | 0.80 | AR (0.53) | ABL1RPA1 | |
| SCHEMBL15754423 | 0.79 | RPA1 (0.50) | SMN1; SMN2TSHRRPA1ALDH1A1L3MBTL1 | |
| SCHEMBL31587999 | 0.78 | POLB (0.58) | ALDH1A1L3MBTL1NOTUMTDP1POLB | |
| SCHEMBL5064593 | 0.76 | AVPR2 (0.55) | MYCNR4A1SMN1; SMN2TSHRCASP1 | |
| SCHEMBL14812729 | 0.75 | KMT2A (0.44) | TSHRSIGMAR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572694-B1 | PYRROLO[2,1-C][1,4] BENZODIAZEPINES AS VASOPRESSIN AGONISTS | WYETH CORP (US) | 2008-10-08 | — | — | EP | disclosed |
| US-7138393-B2 | Biologically active vasopressin agonist metabolites | WYETH (US) | 2006-11-21 | — | — | US | disclosed |
| CN-1745083-A | Pyrrolo [2, 1-c ] [1,4] benzodiazepines as vasopressin agonists | WYETH CORP (US) | 2006-03-08 | — | — | CN | disclosed |
| EP-1572694-A1 | PYRROLO'2,1-C!'1,4! BENZODIAZEPINES AS VASOPRESSIN AGONISTS | Wyeth (US) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004060894-A1 | PYRROLO`2,1-C!`1,4! BENZODIAZEPINES AS VASOPRESSIN AGONISTS | WYETH (US) | 2004-07-22 | — | — | WO | disclosed |
| WO-2004060894-A1 | PYRROLO`2,1-C!`1,4! BENZODIAZEPINES AS VASOPRESSIN AGONISTS | WYETH (US) | 2004-07-22 | — | — | WO | disclosed |
| US-20030134845-A1 | Biologically active vasopressin agonist metabolites | WYETH (US) | 2003-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030134845-A1 | Biologically active vasopressin agonist metabolites | AVPR2, AVPR1A, AVPR1B | MYC 4793/4885NR4A1 1262/4885SMN1; SMN2 1895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.