⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27729882 | 0.84 | HCAR2 (0.39) | — | |
| SCHEMBL930682 | 0.82 | — | — | |
| SCHEMBL12270026 | 0.80 | — | — | |
| SCHEMBL159502 | 0.77 | — | — | |
| SCHEMBL1827221 | 0.77 | MAPK1 (0.47) | — | |
| SCHEMBL159501 | 0.77 | — | — | |
| SCHEMBL6713436 | 0.77 | — | — | |
| SCHEMBL15556627 | 0.76 | — | — | |
| SCHEMBL20029123 | 0.76 | — | — | |
| SCHEMBL30587528 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3708165-B1 | CRYSTAL FORM I OF A 5-AMINOPYRAZOLE CARBOXAMIDE COMPOUND AS BTK INHIBITOR | SINOMAB BIOSCIENCE LTD (CN) | 2023-01-18 | — | — | EP | claimed |
| EP-3459940-B1 | 5-AMINOPYRAZOLE CARBOXAMIDE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | SUZHOU SINOVENT PHARMACEUTICALS CO LTD (CN) | 2022-07-20 | — | — | EP | claimed |
| US-11180475-B2 | Crystal form I of a 5-aminopyrazole carboxamide compound as BTK inhibitor | SINOMAB BIOSCIENCE LIMITED (HK) | 2021-11-23 | — | — | US | claimed |
| CN-111212644-B | Amorphous solid dispersions of 5-aminopyrazole carboxamide compounds as BTK inhibitors | 苏州信诺维医药科技有限公司 | 2021-01-15 | — | — | CN | claimed |
| US-10882843-B2 | 5-aminopyrazole carboxamide derivative as BTK inhibitor and preparation method and pharmaceutical composition thereof | Suzhou Sinovent Pharmaceuticals Co., Ltd. (CN) | 2021-01-05 | — | — | US | claimed |
| CN-111225669-B | Crystalline form I of 5-aminopyrazole carboxamide compounds as BTK inhibitors | 苏州信诺维医药科技有限公司 | 2020-12-29 | — | — | CN | claimed |
| US-20200361902-A1 | CRYSTAL FORM I OF A 5-AMINOPYRAZOLE CARBOXAMIDE COMPOUND AS BTK INHIBITOR | SUZHOU SINOVENT PHARMA CO., LTD. (CN) | 2020-11-19 | — | — | US | claimed |
| EP-3708165-A1 | CRYSTAL FORM I OF A 5-AMINOPYRAZOLE CARBOXAMIDE COMPOUND AS BTK INHIBITOR | Sinomab Bioscience Limited (CN) | 2020-09-16 | — | — | EP | claimed |
| CN-107382973-B | 5-aminopyrazole carboxamide derivatives as BTK inhibitors, process for their preparation and pharmaceutical compositions containing them | 苏州信诺维医药科技有限公司 | 2020-08-07 | — | — | CN | claimed |
| CN-111225669-A | Crystalline form I of 5-aminopyrazole carboxamide compounds as BTK inhibitors | 苏州信诺维医药科技有限公司 | 2020-06-02 | — | — | CN | claimed |
| CN-111225912-A | 5-aminopyrazole carboxamide compounds as BTK inhibitors and preparation method thereof | 苏州信诺维医药科技有限公司 | 2020-06-02 | — | — | CN | claimed |
| CN-111212644-A | Amorphous solid dispersions of 5-aminopyrazole carboxamide compounds as BTK inhibitors | 苏州信诺维医药科技有限公司 | 2020-05-29 | — | — | CN | claimed |
| US-20190152952-A1 | 5-AMINOPYRAZOLE CARBOXAMIDE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | Evopoint Biosciences Co., Ltd. (CN) | 2019-05-23 | — | — | US | claimed |
| EP-3459940-A1 | 5-AMINOPYRAZOLE CARBOXAMIDE DERIVATIVE AS BTK INHIBITOR AND PREPARATION METHOD AND PHARMACEUTICAL COMPOSITION THEREOF | Zhejiang Yukon Pharma Co., Ltd. (CN) | 2019-03-27 | — | — | EP | claimed |
| EP-4720067-A1 | BICYCLIC HETEROARYLAMIDES HAVING GPR68 MODULATING ACTIVITY | Recursion Pharmaceuticals, Inc. (US) | 2026-04-08 | — | — | EP | disclosed |
| WO-2024246559-A1 | BICYCLIC HETEROARYLAMIDES HAVING GPR68 MODULATING ACTIVITY | EXSCIENTIA AI LIMITED (GB) | 2024-12-05 | — | — | WO | disclosed |
| CN-119059970-A | Preparation method of BTK inhibitor drug intermediate | 上海信诺维生物医药有限公司 | 2024-12-03 | — | — | CN | disclosed |
| CN-1326446-A | Method for producing 5-Amino-3-(thio) carbamoylpyrazoles | BAYER AG (DE) | 2001-12-12 | — | — | CN | disclosed |
| EP-1131300-A2 | METHOD FOR PRODUCING 5-AMINO-3-(THIO)CARBAMOYLPYRAZOLES | Bayer Aktiengesellschaft (DE) | 2001-09-12 | — | — | EP | disclosed |
| WO-2000031043-A2 | METHOD FOR PRODUCING 5-AMINO-3-(THIO)CARBAMOYLPYRAZOLES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-06-02 | — | — | WO | disclosed |