Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.65 |
| ▸ | PDE4A | P27815 | 8/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585967 | 0.86 | PDE4B (0.65) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL131830 | 0.85 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL5565347 | 0.85 | PDE4B (0.64) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL128167 | 0.85 | PDE4B (0.70) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7329999 | 0.84 | PDE4D (0.80) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL5309884 | 0.83 | PDE4D (0.67) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL27472680 | 0.83 | PDE4D (0.68) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL7340272 | 0.83 | PDE4D (0.78) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL5349155 | 0.83 | PDE4B (0.67) | PDE4BPDE4DPDE4APDE4CMAPK14 | |
| SCHEMBL1322947 | 0.83 | MAPT (0.61) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7459453-B2 | Pyridazin-3(2H)-one derivatives as PDE4 inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-12-02 | — | — | US | disclosed |
| US-20080269235-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS | DAL PIAZ VITTORIO | 2008-10-30 | — | — | US | disclosed |
| US-20060052379-A1 | Pyridazin-3(2h)-one derivatives as pde4 inhibitors | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-03-09 | — | — | US | disclosed |
| EP-1503992-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | Almirall Prodesfarma, S.A. (ES) | 2005-02-09 | — | — | EP | disclosed |
| WO-2003097613-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AS PDE4 INHIBITORS | ALMIRALL PRODESFARMA SA (ES) | 2003-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269235-A1 | PYRIDAZIN-3 (2H) -ONE DERIVATIVES AS PDE4 INHIBITORS | PDE4A, PDE3A, PDE4B | PDE4B 3/4885PDE4D 9/4885PDE4A 1/4885 |
| US-20060052379-A1 | Pyridazin-3(2h)-one derivatives as pde4 inhibitors | PDE4A, PDE3A, PDE4B | PDE4B 3/4885PDE4D 9/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.