Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.67 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.67 |
| ▸ | PDE4A | P27815 | 10/20 | 0.67 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.67 |
| ▸ | PDE5A | O76074 | 2/20 | 0.67 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.64 |
| ▸ | PDE1A | P54750 | 1/20 | 0.61 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.61 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7364684 | 0.94 | PDE4D (0.60) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL16544973 | 0.91 | MAPT (0.59) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL8461881 | 0.89 | PDE4A (0.79) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL16544967 | 0.88 | MAPT (0.62) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL27472680 | 0.88 | PDE4D (0.68) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL18031253 | 0.88 | MAPT (0.53) | PDE4DPDE4BPDE4APDE4CPDE5A | |
| SCHEMBL30009845 | 0.87 | PDE4B (0.80) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL4728938 | 0.87 | PDE4B (0.80) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL1028427 | 0.87 | PDE4B (0.80) | PDE4DPDE4BPDE4APDE4CMAPK14 | |
| SCHEMBL128167 | 0.87 | PDE4B (0.70) | PDE4DPDE4BPDE4APDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1802615-A1 | PHOSPHODIESTERASE 4 INHIBITORS | Memory Pharmaceuticals Corporation (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044955-A1 | PHOSPHODIESTERASE 4 INHIBITORS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2006-04-27 | — | — | WO | disclosed |
| EP-0607373-B1 | TRISUBSTITUTED PHENYL DERIVATIVES AS SELECTIVE PHOSPHODIESTERASE IV INHIBITORS | CELLTECH THERAPEUTICS LTD (GB) | 1997-03-19 | — | — | EP | disclosed |
| US-5340827-A | Phenylcarboxamide compounds which have useful pharmaceutical activity | CELLTECH, LIMITED (GB) | 1994-08-23 | — | — | US | disclosed |