Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 5/20 | 0.44 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | OXTR | P30559 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3554440 | 0.94 | USP2 (0.47) | LMNASMN1; SMN2NAMPTAVPR1AUSP2 | |
| SCHEMBL3552792 | 0.93 | USP2 (0.47) | LMNASMN1; SMN2NAMPTAVPR1AUSP2 | |
| SCHEMBL3554744 | 0.92 | NAMPT (0.47) | LMNASMN1; SMN2NAMPTAVPR1AUSP2 | |
| SCHEMBL3553460 | 0.92 | AVPR1A (0.52) | LMNASMN1; SMN2NAMPTAVPR1AUSP2 | |
| SCHEMBL3554592 | 0.92 | NAMPT (0.52) | LMNASMN1; SMN2NAMPTAVPR1AVNN1 | |
| SCHEMBL3557245 | 0.91 | NAMPT (0.47) | LMNASMN1; SMN2NAMPTAVPR1AUSP2 | |
| SCHEMBL3550048 | 0.91 | VNN1 (0.47) | LMNASMN1; SMN2NAMPTAVPR1AUSP2 | |
| SCHEMBL3559289 | 0.91 | KMT2A (0.48) | LMNASMN1; SMN2NAMPTAVPR1AVNN1 | |
| SCHEMBL3550414 | 0.90 | STAT3 (0.48) | LMNASMN1; SMN2NAMPTUSP2VNN1 | |
| SCHEMBL3555255 | 0.90 | AVPR1A (0.50) | LMNASMN1; SMN2NAMPTAVPR1AVNN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1893615-A1 | PYRROLOBENZODIAZEPINE PYRIDINE CARBOXAMIDES AND DERIVATIVES AS FOLLICLE-STIMULATING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-03-05 | — | — | EP | claimed |
| WO-2006135687-A1 | PYRROLOBENZODIAZEPINE PYRIDINE CARBOXAMIDES AND DERIVATIVES AS FOLLICLE-STIMULATING HORMONE RECEPTOR ANTAGONISTS | WYETH (US) | 2006-12-21 | — | — | WO | claimed |
| EP-1893615-A1 | PYRROLOBENZODIAZEPINE PYRIDINE CARBOXAMIDES AND DERIVATIVES AS FOLLICLE-STIMULATING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006135687-A1 | PYRROLOBENZODIAZEPINE PYRIDINE CARBOXAMIDES AND DERIVATIVES AS FOLLICLE-STIMULATING HORMONE RECEPTOR ANTAGONISTS | WYETH (US) | 2006-12-21 | — | — | WO | disclosed |