Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 19/20 | 0.72 |
| ▸ | CSF1R | P07333 | 16/20 | 0.72 |
| ▸ | KDR | P35968 | 15/20 | 0.72 |
| ▸ | FLT3 | P36888 | 6/20 | 0.57 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5009418 | 0.88 | KDR (0.56) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL4708414 | 0.87 | PDGFRB (0.73) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL2174909 | 0.85 | PDGFRB (0.82) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL2173586 | 0.84 | PDGFRB (1.00) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL2174490 | 0.82 | PDGFRB (0.69) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL2173264 | 0.82 | PDGFRB (0.78) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL2176270 | 0.82 | PDGFRB (0.66) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL2173476 | 0.80 | PDGFRB (0.67) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL2177245 | 0.80 | PDGFRB (1.00) | PDGFRBCSF1RKDRFLT3PDGFRA | |
| SCHEMBL22089482 | 0.78 | PDGFRA (0.71) | PDGFRBCSF1RKDRFLT3PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | claimed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | claimed |
| EP-1994025-A1 | QUINOLINE DERIVATIVES | AstraZeneca AB (SE) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007099326-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2007-09-07 | — | — | WO | disclosed |