Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 8/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4599690 | 0.80 | APLNR (0.54) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27972158 | 0.77 | APLNR (0.54) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4599436 | 0.74 | APLNR (0.54) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4599467 | 0.74 | APLNR (0.54) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21262083 | 0.72 | CYP1A2 (0.59) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14868266 | 0.72 | APLNR (0.61) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24636086 | 0.71 | APLNR (0.56) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15254630 | 0.71 | CYP1A2 (0.53) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17247657 | 0.71 | APLNR (0.52) | APLNRTSHRCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL18062214 | 0.70 | APLNR (0.59) | APLNRTSHRCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |