Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
| ▸ | APP | P05067 | 7/20 | 0.55 |
| ▸ | VCP | P55072 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710988 | 1.00 | JUN (0.59) | JUNNFKB1APPVCPNPC1 | |
| SCHEMBL4710991 | 0.87 | APP (0.62) | NFKB1APPNPC1RAB9AMAPT | |
| SCHEMBL4710990 | 0.87 | APP (0.62) | NFKB1APPNPC1RAB9AMAPT | |
| SCHEMBL12280667 | 0.85 | KMT2A (0.66) | JUNNFKB1VCPNPC1RAB9A | |
| SCHEMBL3674227 | 0.83 | JUN (0.82) | JUNNFKB1VCPNPC1RAB9A | |
| SCHEMBL3674230 | 0.83 | JUN (0.82) | JUNNFKB1VCPNPC1RAB9A | |
| SCHEMBL4712500 | 0.81 | MAPT (0.48) | NFKB1VCPNPC1RAB9AMAPT | |
| SCHEMBL4712501 | 0.81 | MAPT (0.48) | NFKB1VCPNPC1RAB9AMAPT | |
| SCHEMBL18270549 | 0.81 | JUN (0.79) | JUNNFKB1VCPKMT2AMEN1 | |
| SCHEMBL4711155 | 0.81 | APP (0.84) | NFKB1APPNPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | claimed |
| EP-0998459-A2 | PYRIDINE DERIVATIVES | Novartis AG (CH) | 2000-05-10 | — | — | EP | claimed |
| WO-1999002497-A2 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 1999-01-21 | — | — | WO | claimed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |