Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | STAT3 | P40763 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | AURKA | O14965 | 3/20 | 0.39 |
| ▸ | PLK4 | O00444 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2415167 | 0.85 | MAPT (0.50) | CDK1CDK2CDK4ALDH1A1MAPT | |
| SCHEMBL2416784 | 0.80 | ALDH1A1 (0.59) | ALDH1A1KDM4EMAPTHPGDSTAT3 | |
| SCHEMBL2414379 | 0.78 | AURKA (0.64) | MAPK1AURKAPLK4PRKD3MAP4K4 | |
| SCHEMBL2416882 | 0.77 | MAPT (0.49) | CDK1CDK2CDK4MAPTHSD17B10 | |
| SCHEMBL2415476 | 0.77 | CDK2 (0.44) | CDK1CDK2CDK4ALDH1A1KDM4E | |
| SCHEMBL2416993 | 0.77 | MAPK1 (0.51) | CDK1CDK2CDK4ALDH1A1KDM4E | |
| SCHEMBL2416650 | 0.77 | MAPT (0.48) | CDK1CDK2CDK4ALDH1A1KDM4E | |
| SCHEMBL2420079 | 0.77 | MAPT (0.47) | CDK1CDK2CDK4ALDH1A1KDM4E | |
| SCHEMBL2418883 | 0.76 | PDE7A (0.49) | CDK1CDK2CDK4ALDH1A1KDM4E | |
| SCHEMBL2415661 | 0.76 | MAPT (0.49) | CDK1CDK2CDK4ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530573-B1 | CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-03-19 | — | — | EP | claimed |