Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 4/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 4/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | WNT1 | P04628 | 1/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4710480 | 0.85 | MEN1 (0.46) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| SCHEMBL3736252 | 0.84 | NAMPT (0.42) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| SCHEMBL3742162 | 0.84 | NAMPT (0.42) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| Hydrochloric Acid SCHEMBL3739080 | 0.83 | MAPK1 (0.43) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| Hydrochloric Acid SCHEMBL3739075 | 0.83 | MAPK1 (0.43) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| SCHEMBL3731076 | 0.80 | CCNK (0.42) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| SCHEMBL3731078 | 0.80 | CCNK (0.42) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| SCHEMBL10315552 | 0.71 | ACKR3 (0.57) | ACKR3HTR1AHTR1DHTR1BNPSR1 | |
| SCHEMBL398679 | 0.71 | ACKR3 (0.51) | ACKR3CYP2C9HTR1AHTR1DHTR1B | |
| SCHEMBL401714 | 0.70 | ACKR3 (0.49) | ACKR3HTR1AHTR1DHTR1BNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959963-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | claimed |
| WO-2007089336-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-08-09 | — | — | WO | claimed |