Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 9/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3731076 | 0.88 | CCNK (0.42) | MEN1KMT2AMAPK1FAAHACKR3 | |
| SCHEMBL3731078 | 0.88 | CCNK (0.42) | MEN1KMT2AMAPK1FAAHACKR3 | |
| Hydrochloric Acid SCHEMBL3739080 | 0.87 | MAPK1 (0.43) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| Hydrochloric Acid SCHEMBL3739075 | 0.87 | MAPK1 (0.43) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| SCHEMBL3198046 | 0.86 | ACKR3 (0.52) | FAAHACKR3HTR1AHTR1DHTR1B | |
| SCHEMBL3736252 | 0.85 | NAMPT (0.42) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| SCHEMBL3742162 | 0.85 | NAMPT (0.42) | MEN1KMT2AMAPK1ACKR3ROCK2 | |
| SCHEMBL4711098 | 0.85 | MEN1 (0.40) | MEN1KMT2AMAPK1ACKR3HTR1A | |
| SCHEMBL4721829 | 0.81 | FAAH (0.45) | FAAHACKR3HTR1AHTR1DHTR1B | |
| SCHEMBL3196669 | 0.78 | FAAH (0.47) | MEN1KMT2AFAAHACKR3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959963-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | Cytokinetics, Inc. (US) | 2008-08-27 | — | — | EP | disclosed |
| WO-2007089336-A2 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS AND METHODS | CYTOKINETICS, INC. (US) | 2007-08-09 | — | — | WO | disclosed |