Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 14/20 | 0.50 |
| ▸ | TCF7L2 | Q9NQB0 | 14/20 | 0.50 |
| ▸ | VNN1 | O95497 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2417972 | 0.87 | CTNNB1 (0.45) | CTNNB1TCF7L2AURKANPC1RAB9A | |
| SCHEMBL2979986 | 0.84 | CTNNB1 (0.46) | CTNNB1TCF7L2VNN1AURKARPS6KB1 | |
| SCHEMBL2415426 | 0.79 | LMNA (0.48) | VNN1 | |
| SCHEMBL2416104 | 0.79 | GRM5 (0.46) | NPC1RAB9A | |
| SCHEMBL2417626 | 0.79 | LRRK2 (0.51) | CTNNB1TCF7L2PIM1AURKANPC1 | |
| SCHEMBL2410908 | 0.78 | PTPN11 (0.50) | NPC1RAB9A | |
| SCHEMBL2411898 | 0.77 | TMPRSS4 (0.46) | AURKANPC1RAB9A | |
| SCHEMBL2412370 | 0.77 | ITK (0.47) | CTNNB1TCF7L2AURKANPC1RAB9A | |
| SCHEMBL2411619 | 0.76 | NR1H4 (0.45) | AURKANPC1RAB9A | |
| SCHEMBL2415985 | 0.76 | BDKRB1 (0.49) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1530573-B1 | CONDENSED HETEROCYCLIC PYRAZOLE DERIVATIVES AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2008-03-19 | — | — | EP | claimed |