Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 18/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4709303 | 0.78 | LTA4H (0.52) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4692982 | 0.78 | LTA4H (0.64) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22224242 | 0.78 | LTA4H (0.62) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4693439 | 0.78 | LTA4H (0.51) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL2170240 | 0.77 | LTA4H (0.62) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4708073 | 0.77 | LTA4H (0.58) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL22224212 | 0.75 | LTA4H (0.58) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| Ammonia Solution, Strong SCHEMBL4693064 | 0.75 | LTA4H (0.52) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2169641 | 0.75 | LTA4H (0.62) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL11471037 | 0.74 | CYP1A2 (0.73) | LTA4HKCNH2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660491-B1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2008-08-06 | — | — | EP | claimed |
| EP-1660491-A1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-05-31 | — | — | EP | claimed |
| WO-2005012296-A1 | BENZIMIDAZOLE, BENZTHIAZOLE AND BENZOXAZOLE DERIVATIVES AND THEIR USE AS LTA4H MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-02-10 | — | — | WO | claimed |