Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.55 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.55 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.55 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.55 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.55 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.55 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.55 |
| ▸ | TYMP | P19971 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 4/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6887845 | 0.92 | LMNA (0.77) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL3853209 | 0.92 | LMNA (0.77) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL14075781 | 0.92 | LMNA (0.77) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL13264312 | 0.92 | LMNA (0.77) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL14030780 | 0.92 | LMNA (0.77) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL14088746 | 0.92 | LMNA (0.77) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL10001661 | 0.92 | LMNA (0.77) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL3163131 | 0.92 | LMNA (0.77) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL20857283 | 0.89 | LMNA (0.65) | LMNAALDH1A1TP53MAPTTDP1 | |
| SCHEMBL6363723 | 0.89 | LMNA (0.70) | LMNAALDH1A1TP53MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2345661-A1 | Modified fluorinated nucleoside analogues | Pharmasset, Inc. (US) | 2011-07-20 | — | — | EP | disclosed |