SCHEMBL471180

SCHEMBL471180

O=C(O)/C=C/C1=CCCCC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.44
CYP1A2 P05177 1/20 0.39
HCAR2 Q8TDS4 4/20 0.38
HDAC4 P56524 3/20 0.38
HDAC2 Q92769 3/20 0.38
HDAC8 Q9BY41 3/20 0.38
HDAC6 Q9UBN7 3/20 0.38
HDAC3 O15379 2/20 0.38
HDAC1 Q13547 2/20 0.38
HDAC7 Q8WUI4 2/20 0.38
HDAC10 Q969S8 2/20 0.38
HDAC11 Q96DB2 2/20 0.38
HDAC9 Q9UKV0 2/20 0.38
HDAC5 Q9UQL6 2/20 0.38
TNKS O95271 1/20 0.38
TNKS2 Q9H2K2 1/20 0.38
PIN1 Q13526 1/20 0.37
LMNA P02545 2/20 0.36
HPGD P15428 2/20 0.36
NPC1 O15118 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4195192 1.00 TAAR1 (0.44) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL7353784 0.98 TAAR1 (0.43) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL4190776 0.98 TAAR1 (0.43) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL7353792 0.98 TAAR1 (0.43) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL7353777 0.98 TAAR1 (0.43) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL2787551 0.98 TAAR1 (0.43) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL4188530 0.94 HCAR2 (0.39) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL9474747 0.94 HCAR2 (0.39) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL9578841 0.93 TAAR1 (0.40) TAAR1CYP1A2HCAR2HDAC4HDAC2
SCHEMBL10378479 0.87

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2046804-B1 Synthesis of diethyl{[5-(3-fluorophenyl)-pyridine-2-yl]methyl} phosphonate used in the synthesis of himbacine analogs MERCK SHARP & DOHME (US) 2015-07-15 EP disclosed
EP-2399912-A2 An exo-selective synthesis of himbacine analogs Schering Corporation (US) 2011-12-28 EP disclosed
EP-2206697-A1 Exo- and diastereo-selective syntheses of himbacine analogs SCHERING CORPORATION (US) 2010-07-14 EP disclosed
EP-1848705-B1 EXO- AND DIASTEREO- SELECTIVE SYNTHESES OF HIMBACINE ANALOGS SCHERING CORP (US) 2010-02-24 EP disclosed
WO-2008005348-A1 SYNTHESIS OF DIETHYL{ I5' (3 -FLUOROPHENYL) -PYRIDINE-2-YL] METHYL} PHOSPHONATE USED IN THE SYNTHESIS OF HIMBACINE ANALOGS SCHERING CORPORATION (US) 2008-01-10 WO disclosed
EP-1036072-B1 THROMBIN RECEPTOR ANTAGONISTS SCHERING CORP (US) 2004-05-06 EP disclosed
US-6326380-B1 CARDIOVASCULAR DISORDERS; ANTICANCER AGENTS SCHERING CORPORATION 2001-12-04 US disclosed
US-6063847-A TREATMENT OF DISEASES RELATED TO THROMBOSIS AS FOR EXAMPLE ATHELOSCLEROSIS, ANGINA PECTORIS, HEART FAILURE; HYPOTENSIVE AGENTS, ANTIARRYTHMIA AGENTS SCHERING CORPORATION (US) 2000-05-16 US disclosed