Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 14/20 | 0.65 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4712675 | 0.82 | HSD11B1 (0.60) | KDM4E | |
| SCHEMBL3638832 | 0.81 | GRM5 (0.60) | GRM5ACACBKDM4EALDH1A1 | |
| SCHEMBL4713781 | 0.80 | GRM5 (0.51) | GRM5KDM4EALDH1A1 | |
| SCHEMBL22353354 | 0.75 | HPGD (0.56) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4714004 | 0.75 | GRM5 (0.47) | GRM5TRPM8KDM4E | |
| SCHEMBL4711926 | 0.74 | GRM5 (0.45) | GRM5 | |
| SCHEMBL1658127 | 0.72 | GRM5 (0.59) | GRM5TRPM8 | |
| SCHEMBL4710819 | 0.71 | GRM5 (0.58) | GRM5KDM4EALDH1A1 | |
| SCHEMBL20260141 | 0.70 | HPGD (0.58) | KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL16719440 | 0.70 | ACACB (0.58) | GRM5ACACBKDM4EALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |