Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.56 |
| ▸ | HPGD | P15428 | 10/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.56 |
| ▸ | TSHR | P16473 | 7/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | GLA | P06280 | 5/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 3/20 | 0.42 |
| ▸ | CASP7 | P55210 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8242946 | 0.85 | KDM4E (0.42) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4710577 | 0.84 | ALDH1A1 (0.53) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4710695 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4708647 | 0.81 | KDM4E (0.49) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4712720 | 0.81 | KDM4E (0.49) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4709648 | 0.78 | KDM4E (0.68) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4708926 | 0.76 | KDM4E (0.44) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4710265 | 0.76 | ALDH1A1 (0.44) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4711135 | 0.75 | HSD17B10 (0.58) | ALDH1A1KDM4EHPGDHSD17B10TSHR | |
| SCHEMBL4713044 | 0.74 | ALDH1A1 (0.95) | ALDH1A1KDM4EHPGDHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1957475-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merz Pharma GmbH & Co.KGaA (DE) | 2008-08-20 | — | — | EP | disclosed |
| WO-2007045876-A1 | CHROMENONES AND THEIR USE AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2007-04-26 | — | — | WO | disclosed |