Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493718 | 0.87 | CHRNB2 (0.35) | MEN1KMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL493325 | 0.83 | CHRM1 (0.35) | KMT2AALDH1A1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL493789 | 0.78 | IDO1 (0.35) | ALDH1A1HTR2ASLC6A4SLC6A3 | |
| SCHEMBL644085 | 0.73 | CHRNB2 (0.34) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B2 | |
| SCHEMBL493236 | 0.72 | KDM4E (0.36) | ALDH1A1 | |
| SCHEMBL493235 | 0.72 | KDM4E (0.36) | ALDH1A1 | |
| SCHEMBL2306988 | 0.72 | KDM4E (0.36) | ALDH1A1 | |
| SCHEMBL1328539 | 0.72 | MCHR1 (0.54) | MEN1KMT2AALDH1A1SMN1; SMN2ATM | |
| SCHEMBL494252 | 0.71 | OPRL1 (0.40) | SLC6A4SLC6A3 | |
| SCHEMBL493597 | 0.70 | BCL2A1 (0.46) | SMN1; SMN2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963278-A1 | SUBSTITUTED IMIDAZOLINE DERIVATIVES | Grünenthal GmbH (DE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007079927-A1 | SUBSTITUTED IMIDAZOLINE DERIVATIVES | Grünenthal GmbH (DE) | 2007-07-19 | — | — | WO | disclosed |