Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 7/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | BLM | P54132 | 6/20 | 0.64 |
| ▸ | ADRB1 | P08588 | 6/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.64 |
| ▸ | RECQL | P46063 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 4/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.64 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.64 |
| ▸ | APEX1 | P27695 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.64 |
| ▸ | DRD2 | P14416 | 3/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.64 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.64 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462710 | 0.80 | ADRB2 (0.59) | TDP1ADRB2ADRB1TSHRHIF1A | |
| SCHEMBL141609 | 0.80 | MAPT (0.67) | MAPTTDP1ADRB2KDM4EBLM | |
| SCHEMBL29457616 | 0.80 | MAPT (0.67) | MAPTTDP1ADRB2KDM4EBLM | |
| Norepinephrine SCHEMBL2609 | 0.78 | TDP1 (1.00) | MAPTTDP1ADRB2KDM4EBLM | |
| SCHEMBL22920980 | 0.78 | TDP1 (0.64) | MAPTTDP1ADRB2KDM4EBLM | |
| SCHEMBL11320084 | 0.78 | MAPT (0.64) | MAPTTDP1ADRB2KDM4EBLM | |
| Norepinephrine SCHEMBL2429869 | 0.78 | TDP1 (1.00) | MAPTTDP1ADRB2KDM4EBLM | |
| SCHEMBL2988507 | 0.78 | TDP1 (0.64) | MAPTTDP1ADRB2KDM4EBLM | |
| L-Norepinephrine SCHEMBL3489077 | 0.78 | TDP1 (1.00) | MAPTTDP1ADRB2KDM4EBLM | |
| Norepinephrine SCHEMBL29399946 | 0.78 | TDP1 (1.00) | MAPTTDP1ADRB2KDM4EBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1625126-B1 | IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | disclosed |