Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 10/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 3/20 | 0.64 |
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4714353 | 1.00 | NFE2L2 (0.64) | NFE2L2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL30379533 | 1.00 | NFE2L2 (0.64) | NFE2L2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28801342 | 0.94 | NFE2L2 (0.57) | NFE2L2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL229328 | 0.80 | NPC1 (1.00) | NFE2L2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL31560044 | 0.80 | NPC1 (1.00) | NFE2L2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL2234105 | 0.80 | NFE2L2 (1.00) | NFE2L2NPC1RAB9AGRM4PKM | |
| SCHEMBL9394256 | 0.80 | NPC1 (1.00) | NFE2L2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL229329 | 0.80 | NPC1 (1.00) | NFE2L2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL709991 | 0.79 | NPC1 (0.57) | NFE2L2NPC1RAB9AMEN1KMT2A | |
| SCHEMBL708946 | 0.76 | NPC1 (0.64) | NFE2L2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116120224-A | Synthesis method of chiral beta-aza-arene tertiary carbon center compound | 河南工业大学 | 2023-05-16 | — | — | CN | disclosed |
| EP-0998459-B1 | PYRIDINE DERIVATIVES | NOVARTIS AG (CH) | 2008-04-23 | — | — | EP | disclosed |
| US-6656957-B1 | Marked and selective modulating, especially antagonistic, action at human metabotropic glutamate receptors (mGluRs); treatment of disorders such as epilepsy, cerebral ischemias, especially acute ischemias, spasticity etc. | NOVARTIS AG (CH) | 2003-12-02 | — | — | US | disclosed |