Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.50 |
| ▸ | LATS1 | O95835 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.49 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | MARK3 | P27448 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5386409 | 0.78 | HSD17B10 (0.74) | GSK3BMAPK1CDC7DYRK3ROCK2 | |
| SCHEMBL5380085 | 0.77 | HSD17B10 (0.77) | GSK3BMAPK1CDC7DYRK3ROCK2 | |
| SCHEMBL696744 | 0.76 | GSK3B (0.73) | GSK3BLATS1CYP1A2CYP2D6 | |
| SCHEMBL8234326 | 0.76 | GSK3B (0.73) | GSK3BLATS1CYP1A2CYP2D6 | |
| SCHEMBL5383596 | 0.74 | MEN1 (0.74) | GSK3BLATS1MAPK1CDC7DYRK3 | |
| SCHEMBL12207766 | 0.74 | HSD17B10 (0.53) | GSK3BMAPK1CDC7DYRK3ROCK2 | |
| SCHEMBL698145 | 0.72 | GSK3B (0.71) | GSK3BLATS1CYP1A2CYP2D6 | |
| SCHEMBL5381034 | 0.72 | HSD17B10 (0.58) | GSK3BMAPK1CDC7DYRK3ROCK2 | |
| SCHEMBL5390633 | 0.69 | GSK3B (0.62) | GSK3BMAPK1CDC7DYRK3ROCK2 | |
| SCHEMBL5377975 | 0.68 | GSK3B (1.00) | GSK3BMAPK1CDC7DYRK3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2001863-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | Mitsubishi Tanabe Pharma Corporation (JP) | 2008-12-17 | — | — | EP | disclosed |
| WO-2007119463-A1 | 2-(CYCLIC AMINO)-PYRIMIDONE DERIVATIVES AS TPK1 INHIBITORS | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2007-10-25 | — | — | WO | disclosed |