Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | GSK3B | P49841 | 10/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.53 |
| ▸ | CDC7 | O00311 | 3/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PIM1 | P11309 | 2/20 | 0.53 |
| ▸ | PRKACA | P17612 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 2/20 | 0.53 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.53 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5380085 | 0.99 | HSD17B10 (0.77) | HSD17B10MEN1KMT2AGSK3BLMNA | |
| SCHEMBL5383596 | 0.87 | MEN1 (0.74) | HSD17B10MEN1KMT2AGSK3BLMNA | |
| SCHEMBL5381034 | 0.87 | HSD17B10 (0.58) | HSD17B10MEN1KMT2AGSK3BLMNA | |
| SCHEMBL15452734 | 0.83 | HSD17B10 (0.76) | HSD17B10MEN1KMT2ALMNAKDM4E | |
| SCHEMBL4714445 | 0.78 | GSK3B (0.50) | HSD17B10MEN1KMT2AGSK3BLMNA | |
| SCHEMBL5386406 | 0.77 | HSD17B10 (0.45) | HSD17B10MEN1KMT2AGSK3BKDM4E | |
| SCHEMBL7447432 | 0.75 | HSD17B10 (0.47) | HSD17B10MEN1KMT2AGSK3BKDM4E | |
| SCHEMBL5377580 | 0.73 | GSK3B (0.87) | HSD17B10GSK3BALDH1A1ROCK2CDC7 | |
| SCHEMBL20012118 | 0.72 | GSK3B (0.50) | HSD17B10MEN1KMT2AGSK3BROCK2 | |
| SCHEMBL11863248 | 0.71 | TSHR (0.59) | HSD17B10MEN1KMT2ALMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7256199-B1 | Pyrimidone derivatives | MITSUBISHI CHEMICAL CORPORATION (JP) | 2007-08-14 | — | — | US | disclosed |
| EP-1115721-B1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEM CORP (JP) | 2003-12-10 | — | — | EP | disclosed |
| EP-1115721-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000018758-A1 | PYRIMIDONE DERIVATIVES | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-04-06 | — | — | WO | disclosed |