Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SUCNR1 | Q9BXA5 | 5/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.38 |
| ▸ | ITGAV | P06756 | 7/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 5/20 | 0.38 |
| ▸ | ITGB5 | P18084 | 5/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.37 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.37 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.35 |
| ▸ | FNTA | P49354 | 2/20 | 0.35 |
| ▸ | FNTB | P49356 | 2/20 | 0.35 |
| ▸ | OXGR1 | Q96P68 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4720078 | 0.82 | ITGAV (0.57) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL4718116 | 0.78 | ITGB3 (0.53) | ITGB3ITGAVITGA2BITGB5NAMPT | |
| SCHEMBL14222776 | 0.77 | GRIN1 (0.49) | NAMPTPRMT5WDR77 | |
| SCHEMBL4718124 | 0.77 | ITGB3 (0.51) | ITGB3ITGAVITGA2BITGB5NAMPT | |
| SCHEMBL4714889 | 0.77 | ITGAV (0.55) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL4715035 | 0.76 | NAMPT (0.43) | NAMPTPRMT5WDR77 | |
| SCHEMBL4715180 | 0.74 | ITGAV (0.53) | ITGB3ITGAVITGA2BITGB5ITGB1 | |
| SCHEMBL13719339 | 0.71 | SUCNR1 (0.58) | SUCNR1OXGR1 | |
| SCHEMBL4714688 | 0.70 | NAMPT (0.41) | ITGB3ITGAVITGA2BITGB5NAMPT | |
| SCHEMBL4789561 | 0.70 | ITGAV (0.57) | ITGB3ITGAVITGA2BITGB5ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216230-B1 | FUSED CYCLOHEPTANE AND FUSED AZACYCLOHEPTANE COMPOUNDS AND THEIR USE AS INTEGRIN RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2008-04-23 | — | — | EP | disclosed |